Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients.

نویسندگان

  • João Guilherme Fiorani Borgio
  • Leonardo Baldaçara
  • Walter dos Santos Moraes
  • Acioly L T Lacerda
  • Maria Beatriz Montaño
  • Andrea Parolin Jackowski
  • Sérgio Tufik
  • Luiz Roberto Ramos
  • Rodrigo Affonseca Bressan
چکیده

OBJECTIVE To evaluate the combination of two factors: clinical dementia rating sum of boxes scores (CDR-SB) and hippocampal volume (HV) as predictors of conversion from mild cognitive impairment (MCI) to dementia. METHODS Twenty-eight individuals (9 normal and 19 with MCI) were classified according to their CDR sum of boxes scores into 3 groups. RESULTS The hippocampal volume was significantly lower in the high-risk group and in those who developed dementia after two years. The rate of conversion was crescent among the three groups. CONCLUSION We were proposed an additional measurement of the hippocampal volume which may be helpful in the prognosis. However, we noted that the CDR-SB is a method as efficient as neuroimaging to predict dementia with the advantage of being a procedure for low cost and easy implementation, more consistent with public policy.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline.

OBJECTIVE To use functional MRI (fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI). METHODS 25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning. A hypothesis driven analysis of fMRI data...

متن کامل

Predicting dementia or diagnosing early stages of Alzheimer's disease? How the hippocampal volume and the Clinical Dementia Rating-SB can help early diagnosis.

Dementia is a devastating age-associated syndrome which is highly prevalent among the elderly. It is an increasing problem with regard to public health costs and the use of services, therefore demanding a great public and family organization and planning, from chronic caregiving to long term institutionalization. Planning for treating dementia, especially Alzheimer’s disease (AD) — its most fre...

متن کامل

Small baseline volume of left hippocampus is associated with subsequent conversion of MCI into dementia: the Göteborg MCI study.

BACKGROUND Earlier studies have reported that hippocampal atrophy can to some extent predict which patients with mild cognitive impairment (MCI) will subsequently convert to dementia, and that converters have an enhanced rate of hippocampal volume loss. OBJECTIVE To further validate the hypothesis that hippocampal atrophy predicts conversion from MCI to dementia, to relate baseline hippocampa...

متن کامل

Validation of the new interpretive guidelines for the clinical dementia rating scale sum of boxes score in the national Alzheimer's coordinating center database.

BACKGROUND It was recently demonstrated that the Clinical Dementia Rating scale Sum of Boxes (CDR-SB) score can be used to accurately stage severity of Alzheimer dementia and mild cognitive impairment (MCI). However, to our knowledge, the utility of those interpretive guidelines has not been cross-validated or applied to a heterogeneous sample of dementia cases. OBJECTIVE To cross-validate th...

متن کامل

Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment.

OBJECTIVE To determine whether clinical assessment methods that grade the severity of impairments within the spectrum of mild cognitive impairment (MCI) can predict clinical course, particularly among very mildly impaired individuals who do not meet formal MCI criteria as implemented in clinical trials. DESIGN Cohort. SETTING Community volunteers. PARTICIPANTS From a longitudinal study of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Arquivos de neuro-psiquiatria

دوره 70 11  شماره 

صفحات  -

تاریخ انتشار 2012